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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Updated: Apr 4, 2026

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[Body composition and comorbidity in the elderly].

Marc Bonnefoy1, Thomas Gilbert2

  • 1Service de médecine gériatrique, Groupement hospitalier Lyon-Sud, Hospices civils de Lyon, France, Unité Inserm 1060 - CaRMeN, Lyon, France, Université Claude Bernard Lyon 1-Faculté Lyon Sud-Ouest, France.

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

Precise body composition analysis, beyond BMI, is crucial for assessing health risks in the elderly. Sarcopenic obesity, common in older adults, presents the worst cardiovascular prognosis and requires better diagnostic tools.

Keywords:
body compositionbody mass indexcomorbidityobesitysarcopenia

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Area of Science:

  • Geriatric Medicine
  • Cardiovascular Health
  • Metabolic Disorders

Background:

  • Obesity and altered body composition increase mortality and morbidity risks.
  • Traditional Body Mass Index (BMI) lacks precision in assessing fat and lean mass distribution.
  • Sarcopenic obesity, prevalent in the elderly, is linked to poor cardiovascular outcomes.

Purpose of the Study:

  • To review the links between body composition and morbidity in the elderly.
  • To emphasize the role of visceral fat and adipokines in cardiovascular risk.
  • To advocate for advanced body composition measurements over BMI in geriatric populations.

Main Methods:

  • Literature review focusing on body composition, sarcopenic obesity, and cardiovascular outcomes.
  • Analysis of the impact of visceral fat and adipokines on geriatric health.
  • Discussion of limitations of BMI in assessing elderly body composition.

Main Results:

  • Sarcopenic obesity represents a significant health challenge in the elderly with the worst cardiovascular prognosis.
  • Visceral fat accumulation is strongly associated with cardiovascular events.
  • Body composition impacts other conditions like dementia, sleep apnea, and cancer.

Conclusions:

  • More precise body composition measurements are needed for the elderly, surpassing the utility of BMI alone.
  • Understanding adipokine interactions with organs is key to managing geriatric health.
  • Accurate body composition assessment is vital for improving prognosis in the elderly.