Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

337
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
337
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.9K
2.9K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

750
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
750
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

482
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
482

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Thyroxine Treatment on Myelination in Premature Neonates With Intraventricular Hemorrhage: An Magnetic Resonance Imaging-Based Approach.

Pediatric neurology·2026
Same author

Reproducibility of hindbrain herniation severity grading on MRI scan in fetuses undergoing prenatal open neural tube defect repair.

Pediatric radiology·2026
Same author

Neuroimaging patterns of brain injury in children following near-drowning.

BMC medical imaging·2025
Same author

Neurodegeneration With Brain Iron Accumulation and Ferroptosis Disorders in Children and Adults: An Imaging Review.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2025
Same author

Artificial Intelligence Implementation in Pediatric Radiology for Patient Safety: A Multisociety Statement From the ACR, ESPR, SPR, SLARP, AOSPR, SPIN.

Journal of the American College of Radiology : JACR·2025
Same author

Congenital Heart Disease and Neurodevelopment: Can Advanced Anatomical and Functional MRI Solve the Unknown?

Radiology·2025
Same journal

The radiographic bubbly fecal pattern of intestinal pneumatosis in newborns revisited.

Pediatric radiology·2026
Same journal

Regional differences in fetal fat accretion in small-for-gestational-age fetuses assessed by quantitative magnetic resonance imaging.

Pediatric radiology·2026
Same journal

Thermal ablation of lung metastases in children: what every paediatric radiologist should know.

Pediatric radiology·2026
Same journal

Prediction of early recurrence in primary intussusception: development of an ultrasound-based radiomics and deep learning nomogram.

Pediatric radiology·2026
Same journal

Pediatric SARS-CoV-2 long term outcomes study: chest radiographic and computed tomography findings at baseline.

Pediatric radiology·2026
Same journal

Pediatric radiology informatics within a larger academic practice.

Pediatric radiology·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

1.1K

Pediatric brain tumors.

Tina Y Poussaint1, Ashok Panigrahy, Thierry A G M Huisman

  • 1Department of Radiology, 300 Longwood Ave., Boston, MA, 02115, USA, TinaYoung.Poussaint@childrens.harvard.edu.

Pediatric Radiology
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

Pediatric brain tumors are the leading cause of cancer death in children. This review covers imaging, molecular, and treatment advances for these tumors, including common mimics.

More Related Videos

Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
11:14

Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

Published on: September 24, 2014

16.3K
Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
03:13

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 4, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

1.1K
Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
11:14

Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

Published on: September 24, 2014

16.3K
Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
03:13

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

1.6K

Area of Science:

  • Pediatric oncology
  • Neuroradiology
  • Molecular diagnostics

Background:

  • Pediatric brain tumors represent the most frequent cause of cancer-related mortality in children.
  • Understanding tumor mimics is crucial for accurate diagnosis.

Purpose of the Study:

  • To provide an overview of infratentorial and supratentorial pediatric brain tumors.
  • To focus on tumor imaging characteristics, molecular advancements, and therapeutic strategies.
  • To review imaging features of common tumor mimics.

Main Methods:

  • Literature review of pediatric brain tumors.
  • Analysis of imaging features for tumor identification.
  • Review of molecular advances and treatment options.
  • Examination of imaging characteristics of tumor mimics.

Main Results:

  • Detailed discussion of imaging findings for specific pediatric brain tumor subsets.
  • Highlighting key molecular alterations driving tumor development and therapeutic targets.
  • Presentation of diagnostic criteria for differentiating tumors from mimics on imaging.

Conclusions:

  • Accurate diagnosis of pediatric brain tumors relies on understanding advanced imaging and molecular profiles.
  • Distinguishing tumors from mimics through imaging is essential for timely and appropriate patient management.
  • Integrated approach combining imaging, molecular data, and clinical context improves outcomes.