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Klotho, stem cells, and aging.

Ao Bian1, Javier A Neyra2, Ming Zhan3

  • 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA ; Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Clinical Interventions in Aging
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

The antiaging protein klotho suppresses Wnt signaling, preventing stem cell depletion and tissue aging. Klotho may offer therapeutic benefits for age-related diseases.

Keywords:
Wntagingcell senescenceklothostem cells

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Stem Cell Biology

Background:

  • Aging is a complex biological process influenced by genetic and acquired factors.
  • Klotho is an antiaging protein that suppresses aging through various mechanisms.
  • Klotho deficiency is linked to Wnt activation, stem cell depletion, and tissue aging.

Purpose of the Study:

  • To investigate the role of klotho in regulating stem cells.
  • To understand the molecular mechanisms underlying klotho's antiaging effects.
  • To explore klotho as a potential therapeutic target for aging and related diseases.

Main Methods:

  • The study focuses on the molecular mechanisms of klotho's action.
  • Investigated the interplay between klotho, Wnt signaling, and stem cell function.
  • Utilized existing literature and molecular pathway analysis.

Main Results:

  • Klotho protein suppresses Wnt signaling, inhibiting cell senescence.
  • Klotho preserves stem cell populations, counteracting depletion.
  • Klotho deficiency exacerbates Wnt activity, leading to tissue atrophy and fibrosis.

Conclusions:

  • Klotho plays a critical role in suppressing aging and maintaining stem cell homeostasis.
  • Understanding klotho's effects on stem cells provides insights into aging mechanisms.
  • Klotho protein shows promise as a therapeutic agent for aging and age-related disorders.