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Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown

Estelle Naumburg1,2, Inge Axelsson3, Daniel Huber2

  • 1Department of Clinical Science, Paediatrics, Umeå University, Umeå, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|September 9, 2015
PubMed

Insights

Premature birth significantly increases the risk of developing adult pulmonary hypertension. This association persists even after accounting for other known risk factors, suggesting unknown contributors.

Area of Science:

  • Cardiology
  • Pediatrics
  • Public Health

Background:

  • Pulmonary hypertension (PH) is associated with premature birth, chronic lung disease, bronchopulmonary dysplasia, and congenital heart disease.
  • Understanding the long-term risks of premature birth is crucial for public health initiatives.

Purpose of the Study:

  • To assess the risk of adult pulmonary hypertension following premature birth.
  • To adjust for known risk factors in this association.

Main Methods:

  • A national population-based registry study using the Swedish Pulmonary Arterial Hypertension Registry.
  • Inclusion of adults born prematurely and randomly selected controls matched by birth year and delivery hospital.
  • Conditional multiple logistic regression analysis to evaluate the association and control for confounders.

Main Results:

  • The study included 427 adults (61 cases, 366 controls) born between 1973 and 1996.
  • Adult pulmonary hypertension was associated with premature birth (Odds Ratio: 3.08, 95% CI: 1.21-7.87).
  • This association remained significant after adjusting for potential confounding factors.

Conclusions:

  • Premature birth is an independent risk factor for adult pulmonary hypertension.
  • The persistent association suggests that unknown factors contribute to the risk of PH in adults born prematurely.
  • Further research is needed to identify these unknown factors.
Abstract

Keywords:
Brochopulmonary dysplasiaChronic lung diseasePremature birthPulmonary HypertensionRisk factors

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