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Updated: Apr 4, 2026

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Published on: September 4, 2016
Delayed Hypersensitivity Reaction: An Increasingly Recognized Complication of Metal-on-Metal Total Disc Replacement
Mélodie-Anne Karnoub1, Fahed Zairi1, Rabih Aboukais1
1Department of Neurosurgery, Lille University Hospital, CHRU de Lille, 59000 Lille, France.
Abstract:
We report the case of a 32-year-old woman who presented with pain recurrence 20 months after she underwent a C5C6 metal-on-metal total replacement. Plan radiographs demonstrated a modification of the shape of the vertebral bodies making the prosthesis more protruding. Then, infection has been ruled out and patch testing revealed a strongly positive reaction for chromium and cobalt. The prosthesis has been removed and a fusion achieved using a cage filled with bone graft. She has been immediately and fully relieved from her pain. We report the radiological signs that enabled early diagnosis and treatment allowing favorable outcome.
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