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Frailty and physical function in chronic kidney disease: the CanFIT study
Simon R Walker1, Ranveer Brar1, Frederick Eng1
1Seven Oaks Hospital, 2PD-13 2300 McPhillips Street, Winnipeg, Manitoba R2V 3M3 Canada.
Canadian Journal of Kidney Health and Disease
|September 9, 2015
Summary
People with advanced chronic kidney disease (CKD) often experience reduced physical function, particularly those with diabetes. Further research is ongoing to understand the progression of frailty in this population.
Area of Science:
- Gerontology
- Nephrology
- Clinical Medicine
Background:
- Frailty is common in chronic kidney disease (CKD) patients and linked to comorbidities.
- Longitudinal data on frailty progression in advanced non-dialysis CKD is limited.
Purpose of the Study:
- To determine the natural history of frailty in advanced CKD.
- To assess frailty prevalence and its association with dialysis choices and outcomes.
Main Methods:
- A 2-year longitudinal observational study of 600 participants with advanced CKD (stage 4-5).
- Utilized multiple frailty measures (SPPB, Fried Criteria, Frailty Index) and assessed outcomes like mortality and dialysis initiation.
- Annual physical and cognitive assessments were conducted.
Main Results:
- Recruited 217 participants; 56% showed reduced physical function at baseline (SPPB).
- Diabetes significantly increased the risk of reduced physical function (8-fold) after adjustments.
Conclusions:
- Advanced CKD patients exhibit a high prevalence of reduced physical function, especially those with diabetes.
- The Canadian Frailty Observation and Interventions Trial (CanFIT) continues enrollment to further elucidate CKD and frailty.
- Limitations include the referred population and initial cross-sectional analysis.
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