Related Experiment Video
Updated: Apr 4, 2026

Bronchoalveolar Lavage BAL for Research; Obtaining Adequate Sample Yield
Published on: March 24, 2014
Quality assessment of acute viral bronchiolitis clinical practice guidelines
Carlos E Rodriguez-Martinez1,2,3, Monica P Sossa-Briceño4, Ranniery Acuña-Cordero5,6
1Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.
Insights
This study evaluated clinical practice guidelines (CPGs) for infant bronchiolitis, finding significant quality variations. Future CPGs need improvement in applicability and stakeholder involvement for better clinical practice.
Area of Science:
- Pediatrics
- Clinical Practice Guidelines
- Respiratory Illnesses
Background:
- Clinical practice guidelines (CPGs) aim to standardize bronchiolitis diagnosis and management in infants.
- Systematic evaluation of the quality of existing CPGs for bronchiolitis is lacking.
Purpose of the Study:
- To systematically assess the quality of clinical practice guidelines (CPGs) for acute viral bronchiolitis in infants.
- Identify areas for improvement in CPG development for bronchiolitis management.
Main Methods:
- A systematic search identified CPGs for bronchiolitis published between 2000 and 2014.
- The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument was used by three independent appraisers.
- CPGs were scored across six domains and rated as recommended, recommended with modifications, or not recommended.
Main Results:
- Six CPGs were selected from 111 citations; high inter-appraiser agreement was observed (ICC: 0.75).
- Highest scores were for 'scope and purpose' (92.1%) and 'clarity of presentation' (83.3%).
- Lowest scores were for 'applicability' (44.3%) and 'stakeholder involvement' (66.7%). Three CPGs were recommended with modifications, and two were recommended.
Conclusions:
- Existing CPGs for infant bronchiolitis exhibit variable quality.
- Significant room for improvement exists in the applicability and stakeholder involvement domains of CPGs.
- Findings highlight specific areas for enhancing future CPG development and implementation.
Rationale, Aims And Objectives:
Recently, in an attempt to reduce variability in clinical practice and produce better results for patients, several clinical practice guidelines (CPGs) for the appropriate diagnosis and management of bronchiolitis in infants have been developed. However, the quality of available CPGs for bronchiolitis management has not yet been systematically evaluated. The aim of this study was to assess the quality of acute viral bronchiolitis CPGs.
Method:
We performed a systematic and exhaustive search of CPGs on bronchiolitis published from 2000 to 2014. Three independent appraisers assessed the quality of the CPGs using the Appraisal of Guidelines Research and Evaluation (AGREE) II instrument. A standardized score was calculated for each of the six domains, and the CPGS were rated as recommended, recommended with modifications, or not recommended.
Results:
Six CPGs published between the years 2000 and 2014 were selected from a total of 111 citations. There was substantial agreement among reviewers (ICC: 0.75; 95% CI, 0.61-0.89). The domains that scored the highest were 'scope and purpose', with a mean value of 92.1% (range: 77.8-100%), and 'clarity of presentation' [83.3% (69.4-91.7%)]. Those that scored the lowest were 'applicability' [44.3% (8.3-77.1%)], and 'stakeholder involvement' [66.7% (47.2-94.4%)]. Three CPGS were evaluated as being recommended with modifications, and only two were recommended for use in clinical practice.
Conclusions:
Available bronchiolitis CPGs vary in quality, and the findings of the present study are useful for identifying aspects or domains where there is room for improvement in future CPGs.
More Related Videos
06:15Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
09:14An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Related Concept Videos
Pneumonia III: Complications and Assessment
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include: