Related Experiment Video
Updated: Apr 4, 2026
Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
Published on: September 19, 2018
Meta-Analysis of Abdominal Aortic Aneurysm in Patients With Coronary Artery Disease
Ahmed Elkalioubie1, Stephan Haulon2, Alain Duhamel3
1European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France.
Insights
Abdominal aortic aneurysm (AAA) is significantly more prevalent in patients with coronary artery disease (CAD). Smoking, hypertension, and carotid artery stenosis are key risk factors for AAA in this population.
Area of Science:
- Cardiovascular Medicine
- Vascular Surgery
- Epidemiology
Background:
- Coronary artery disease (CAD) is common in patients with abdominal aortic aneurysm (AAA).
- The prevalence of AAA in patients with CAD has been less studied.
- Understanding this inverse relationship is crucial for patient risk stratification.
Purpose of the Study:
- To determine the prevalence of AAA in patients with CAD.
- To identify risk factors for AAA in patients with CAD.
- To compare AAA prevalence in CAD patients versus those without CAD.
Main Methods:
- Systematic review and meta-analysis of published evidence.
- Inclusion of 22 studies with 13,388 patients with CAD.
- Pooled analysis to calculate odds ratios (OR) and confidence intervals (CI).
Main Results:
- AAA prevalence in CAD patients was 8.4%, significantly higher than in non-CAD subjects (OR 2.42).
- Smoking (OR 1.72), arterial hypertension (OR 1.57), and carotid artery stenosis (OR 2.14) were significant risk factors for AAA in CAD patients.
- Peripheral artery disease showed a trend towards higher AAA prevalence (OR 2.66, p=0.08).
Conclusions:
- AAA prevalence is significantly elevated in patients with coronary artery disease.
- Specific risk factors like smoking, hypertension, and carotid stenosis increase AAA risk in CAD patients.
- Further research may clarify the association with peripheral artery disease.
Abstract:
The high coronary artery disease (CAD) prevalence in patients with abdominal aortic aneurysm (AAA) is well known. However, the inverse relation has been little explored. We present, based on a systematic review and meta-analysis of the published evidence, a critical appraisal of the issue of AAA prevalence and also AAA predictive risk factors in patients with CAD, comparing it with AAA prevalence in subjects without CAD. A total of 22 studies involving 13,388 patients with CAD met the inclusion criteria. Overall, AAA prevalence in patients with CAD was 8.4% (95% confidence interval [CI] 6.9 to 10.3), significantly higher than in subjects without CAD (odds ratio [OR] 2.42, 95% CI 2.08 to 2.81). Pooled analysis revealed that smoking, arterial hypertension, and concomitant carotid artery stenosis were significantly associated with AAA in patients with CAD (OR 1.72, 95% CI 1.14 to 2.61; OR 1.57, 95% CI 1.06 to 2.35; OR 2.14, 95% CI 1.20 to 3.79, respectively). In patients with CAD, AAA prevalence tended to be higher with concomitant peripheral artery disease (OR 2.66, 95% CI 0.82 to 8.61, p = 0.08). In conclusion, AAA prevalence was significantly higher in patients with CAD versus subjects without CAD.
