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Mefenamic acid: A possible cause of drug-induced acute pancreatitis
S Wurm1, F Schreiber1, W Spindelboeck1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.
Introduction:
Drug-induced acute pancreatitis (AP) is rare, but as there are no systematic data on it, the true incidence is not known.
Case Report:
This case report is a first description of two episodes of AP occurring after administration and subsequent re-administration of mefenamic acid to a young woman without comorbidities. Other common causes of AP could be ruled out. With both episodes, the latency of AP was less than 24 h after drug intake.
Conclusion:
Mefenamic acid should be considered as a possible cause of drug-induced AP.
Insights
Mefenamic acid can cause acute pancreatitis (AP), a rare drug-induced condition. This case report highlights the need to consider this nonsteroidal anti-inflammatory drug as a potential trigger for AP.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Drug-induced acute pancreatitis (AP) is a rare but underreported condition.
- Systematic data on the incidence of drug-induced AP are lacking.
Observation:
- A case report details two episodes of AP in a young woman following mefenamic acid administration.
- Common causes of AP were excluded, and drug re-administration led to recurrent AP.
- The latency period for AP onset was less than 24 hours after mefenamic acid intake.
Findings:
- Mefenamic acid is identified as a potential causative agent for acute pancreatitis.
- The temporal relationship between drug intake and AP onset was observed in two separate episodes.
Implications:
- Clinicians should consider mefenamic acid as a potential cause of drug-induced AP.
- Further research is warranted to establish the true incidence and risk factors for mefenamic acid-induced AP.
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