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Related Concept Videos

Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

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The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
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Cerebrum: Anatomical Overview I01:26

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

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There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
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Organization of the Brain01:30

Organization of the Brain

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The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

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Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
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Arteries of the Head and Neck01:26

Arteries of the Head and Neck

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The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
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Updated: Apr 4, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
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The anatomical problem posed by brain complexity and size: a potential solution.

Javier DeFelipe1

  • 1Laboratorio Cajal de Circuitos Corticales (Centro de TecnologĂ­a BiomĂ©dica: UPM), Instituto Cajal (CSIC) and CIBERNED Madrid, Spain.

Frontiers in Neuroanatomy
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

Understanding the brain's complex wiring remains challenging due to imprecise connection matrices. New methodologies and computational models offer promising solutions for advancing neuroanatomy research.

Keywords:
choice of species for studying the brainconnectomeelectron microscopyinterdisciplinary approachesneuron doctrinesynaptome

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Area of Science:

  • Neuroscience
  • Computational Biology
  • Brain Anatomy

Background:

  • The field of neuroanatomy has advanced significantly, yet a complete understanding of the brain's intricate structure and function remains elusive.
  • A primary obstacle is the difficulty in obtaining precise brain-wide connection matrices, hindering comprehensive analysis.

Purpose of the Study:

  • To discuss the challenges in achieving a complete understanding of brain anatomy and function.
  • To propose novel methodologies and interdisciplinary approaches to overcome current limitations in neuroanatomical research.
  • To highlight the potential of realistic computational models as a viable alternative to full brain reconstruction.

Main Methods:

  • Review of existing neuroanatomical methodologies and their limitations.
  • Discussion of challenges in generating accurate brain connection matrices.
  • Exploration of computational modeling as a tool for understanding brain complexity.

Main Results:

  • Current methods provide imprecise connection matrices, limiting the full reconstruction of brain structure and function.
  • Interdisciplinary collaboration and the development of new study methodologies are crucial for progress.
  • Realistic computational models show promise for simulating brain complexity.

Conclusions:

  • Overcoming the limitations in neuroanatomy requires innovative approaches beyond traditional reconstruction methods.
  • Computational modeling offers a powerful strategy for understanding the brain's structural and functional intricacies.
  • Future advancements in neuroanatomy depend on integrating new technologies and collaborative research efforts.