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Vasospastic Angina in Identical Twins
Takayuki Yoshioka1, Kazunori Otsui1, Atsushi Suzuki1
1Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe Hyogo, Japan.
The American Journal of Case Reports
|September 9, 2015
Summary
Identical twins developed vasospastic angina nearly simultaneously, suggesting a strong genetic influence. This case underscores the importance of considering genetic predisposition in diagnosing coronary artery disease.
Area of Science:
- Cardiology
- Genetics
Background:
- Coronary artery disease (CAD) development is influenced by genetic and environmental factors.
- Genetic mutations and polymorphisms are implicated in coronary spasm pathogenesis.
Observation:
- A case of monozygotic identical twins presenting almost simultaneously with vasospastic angina.
- Both twins exhibited similar coronary angiographic findings, including a short left main trunk and proximal left anterior descending artery stenosis.
Findings:
- Acetylcholine infusion induced vasoconstriction in one twin, which was reversed by nitroglycerin, confirming vasospastic angina.
- The simultaneous diagnosis in identical twins strongly suggests a significant genetic component in vasospastic angina.
Implications:
- Genetic factors play a crucial role in the development of vasospastic angina.
- Familial screening for vasospastic angina may be warranted in individuals with an affected identical twin.
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