[The conservative treatment of Peyronie's disease with orgotein]

Results are analyzed of treatment of patients with induratio penis plastica by local application of orgotein. Fifteen patients with clinically manifest disease were the subject of this study; 4-8 mg Orgotein bulk was applied once a week in a total course of 8 to 10 injections. Criteria for the effect of treatment were: regression of the plaque consistency and size; decrease in the erectile deformity; change or disappearance of pain. Seven patients (46.7 per cent) experienced considerable improvement. Absence of effect was observed in one third of the patients. Quickest to be affected was pain and the penetration possibility, while the erectile deformity regressed at a slower rate. No side reactions or intolerance to the preparation were observed. Essential for the occurrence of therapeutic effect was the use of appliance for injection under high pressure. It this treatment fails, surgical management should be considered.