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Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Lagging Strand Synthesis01:59

Lagging Strand Synthesis

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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
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Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Computational Approaches to Nucleic Acid Origami.

Hosna Jabbari1,2, Maral Aminpour1,2, Carlo Montemagno1,2

  • 1Ingenuity Lab , 11421 Saskatchewan Drive, Edmonton, Alberta T6G 2M9, Canada.

ACS Combinatorial Science
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

DNA origami and RNA origami enable complex 3D nanostructures. RNA origami offers advantages but lags in development, highlighting a need for computational advances and interdisciplinary collaboration in nucleic acid nanotechnology.

Keywords:
DNA origamiRNA origamicomputational approachnanotechnology

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Area of Science:

  • Nanotechnology
  • Biomolecular Engineering
  • Computational Science

Background:

  • DNA origami has enabled complex 3D nanostructures for diverse applications.
  • Ribonucleic acid (RNA) origami is an emerging technique offering enhanced stability and compactness.
  • Current development in RNA origami and computational nucleic acid origami significantly lags behind DNA origami.

Purpose of the Study:

  • To review key advancements in experimental and computational DNA and RNA origami.
  • To identify and discuss current challenges in the field of nucleic acid origami.
  • To emphasize the importance of collaboration between experimental and computational researchers.

Main Methods:

  • Review of experimental DNA and RNA origami techniques.
  • Analysis of computational methods for designing and evaluating nucleic acid nanostructures.
  • Synthesis of current research trends and challenges.

Main Results:

  • DNA origami has achieved significant milestones in creating complex 3D structures.
  • RNA origami presents superior structural properties due to RNA's unique characteristics.
  • Computational approaches for nucleic acid origami are underdeveloped, hindering progress.

Conclusions:

  • RNA origami holds great promise but requires further development to match DNA origami.
  • Advancements in computational tools are crucial for accelerating nucleic acid origami research.
  • Interdisciplinary collaboration between experimental nanotechnologists and computer scientists is essential for future progress.