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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Published on: August 21, 2013
Comparison of transforming, antimitotic and chromosomal aberration-inducing properties of melphalan and
1Institute for Drug Research and Control, Warszawa, Poland.
Abstract:
Melphalan and cyclophosphamide, cytostatics used for cancer therapy, were investigated for their ability to induce morphological transformation of embryonic cells of the golden hamster and to evoke structural chromosome aberrations. The antimitotic action of both drugs was also investigated. Cyclophosphamide, under conditions in which it did not produce either structural chromosomal aberrations or exerted cytotoxic action, induced morphological transformation of hamster cells. Under the experimental conditions melphalan induced morphological transformation of hamster cells at concentrations not inducing chromosomal aberrations.
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