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Synthesis and preliminary pharmacological screening of some 8-substituted methylxanthines
A Drabczyńska1, M Pawłowski, M Gorczyca
1Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Polish Journal of Pharmacology and Pharmacy
|July 1, 1989
Abstract:
Methods of synthesis, chemical properties and results of preliminary pharmacological screening for 8-amino substituted derivatives of caffeine (1-3) and 7,8-disubstituted derivatives of 8-aminotheophylline (8-12) have been described. The compounds show weak sedative and antidepressive activity and some of them (2, 10, 12) also small antinociceptive effect.