Related Experiment Video

Updated: Apr 4, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.7K

Update on ventilator-associated pneumonia

Cristina Vazquez Guillamet1, Marin H Kollef

  • 1aDivision of Pulmonary, Critical Care, and Sleep Medicine bDivision of Infectious Diseases, University of New Mexico School of Medicine, Albuquerque, New Mexico cDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Current Opinion in Critical Care
|September 9, 2015
PubMed
Abstract

Insights

Ventilator-associated pneumonia (VAP) is a serious infection in critical care. Awareness of multidrug-resistant pathogens, their risk factors, and updated diagnostics and treatments is crucial for effective management.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Ventilator-associated pneumonia (VAP) is a significant nosocomial infection in intensive care units.
  • Rising antimicrobial resistance poses a major challenge in treating VAP.
  • Identifying risk factors for multidrug-resistant (MDR) pathogens is essential for VAP management.

Purpose of the Study:

  • To emphasize the growing problem of antimicrobial resistance in VAP.
  • To discuss the diagnostic and therapeutic implications of escalating pathogen resistance.
  • To inform clinicians about managing VAP caused by MDR pathogens.

Main Methods:

  • Review of current literature on VAP epidemiology and antimicrobial resistance.
  • Analysis of diagnostic advancements for rapid pathogen identification.
  • Evaluation of treatment strategies to combat MDR VAP and prevent further resistance.

Main Results:

  • VAP continues to be a prevalent infection in critically ill patients, complicated by increasing bacterial resistance.
  • Risk factors for MDR pathogens are influenced by local resistance patterns and patient-specific factors.
  • Novel diagnostic tools and antimicrobial agents offer potential for timely and appropriate VAP treatment, aiding resistance containment.

Conclusions:

  • Clinicians must recognize the risk factors associated with MDR pathogens in VAP.
  • Understanding specific diagnostic and treatment approaches for VAP is critical.
  • Proactive management strategies are necessary to address the challenge of antimicrobial resistance in VAP.

More Related Videos

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.6K
Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation07:15

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Published on: December 5, 2025

660

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.3K
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
2.1K
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
1.1K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
844
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.2K
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
3.8K