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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: June 16, 2020

Cough in Sarcoidosis.

Timothy Tully¹, Surinder S Birring²

¹Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, SE9 5RS, UK.

|September 10, 2015

Summary

This summary is machine-generated.

Sarcoidosis, a lung disorder, causes persistent cough impacting quality of life. Investigating cough mechanisms and considering corticosteroids may help manage this symptom.

Keywords:

Cough Cough reflex hypersensitivity Health related quality of life Sarcoidosis

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Area of Science:

Pulmonology
Immunology
Gastroenterology

Background:

Sarcoidosis is a granulomatous disease primarily affecting the lungs.
Chronic cough is a common and debilitating symptom in sarcoidosis patients.
The precise mechanisms driving sarcoidosis-associated cough remain unclear.

Purpose of the Study:

To explore potential mechanisms underlying cough in sarcoidosis.
To review diagnostic approaches for sarcoidosis-related cough.
To discuss therapeutic strategies and future research directions.

Main Methods:

Literature review of sarcoidosis and cough mechanisms.
Analysis of potential contributing factors including airway inflammation, fibrosis, and neural pathways.
Evaluation of current diagnostic and therapeutic guidelines.

Main Results:

Airway inflammation, mechanical distortion from pulmonary fibrosis, and vagus nerve disruption are implicated in sarcoidosis cough.
Cough reflex hypersensitivity is emerging as a significant factor.
Standard investigations should rule out common cough etiologies like asthma and reflux.

Conclusions:

Corticosteroids may be beneficial for sarcoidosis-associated cough.
Validated outcome measures are crucial for assessing cough severity.
Further research is needed to identify novel therapeutic targets for cough in sarcoidosis.