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Updated: Apr 4, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

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Predictors of aortic pulse wave velocity in the elderly with severe aortic stenosis

Karim El-Chilali1, Heba Farouk2, Mohamed Abdelhafez3

  • 1Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany. karim.elchilali@uk-essen.de.

Aging Clinical and Experimental Research
|September 10, 2015
PubMed

Insights

Aortic pulse wave velocity (AoPWV) is not elevated in elderly patients with severe aortic stenosis (AS). Central systolic blood pressure over 140 mmHg best predicts abnormal AoPWV in this population.

Area of Science:

  • Cardiovascular Physiology
  • Geriatric Medicine
  • Valvular Heart Disease

Background:

  • Aortic pulse wave velocity (AoPWV) predictors in elderly severe aortic stenosis (AS) patients are understudied.
  • Understanding AoPWV is crucial for assessing cardiovascular risk in aging populations with AS.

Purpose of the Study:

  • Compare AoPWV in elderly severe AS patients versus matched controls.
  • Identify independent predictors of AoPWV in elderly severe AS patients.

Main Methods:

  • AoPWV measured during cardiac catheterization in 40 severe AS patients and 20 controls.
  • Statistical analysis including adjusted regression models to identify predictors.
  • Central systolic blood pressure (SBP) and glomerular filtration rate (GFR) assessed.

Main Results:

  • AoPWV was similar between severe AS patients and controls (p=0.198).
  • 68% of elderly severe AS patients had AoPWV within normal age-related reference values.
  • Independent predictors of AoPWV in AS group were central SBP (β=0.45, p=0.001) and GFR (β=-0.29, p=0.023).
  • Central SBP >140 mmHg predicted abnormal AoPWV (≥14.6 m/s) with 100% sensitivity and 70% specificity (p<0.001).

Conclusions:

  • AoPWV is not elevated in elderly patients with severe AS compared to controls.
  • AoPWV is within normal age-specific ranges for most elderly severe AS patients.
  • Central SBP >140 mmHg is the strongest predictor of abnormal AoPWV in this cohort.
Abstract

Keywords:
Aortic pulse wave velocityAortic stenosisElderlyGlomerular filtration rateSystolic blood pressure

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