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Updated: Apr 4, 2026
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Facile fabrication of bactericidal and antifouling switchable chitosan wound dressing through a 'click'-type
Xianghong Wang1, Shuaishuai Yuan2, Yu Guo3
1Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China; State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Abstract:
A facile approach to functionalize chitosan (CS) non-woven surface with the bactericidal and antifouling switchable moieties is presented. Azlactone-cationic carboxybetaine ester copolymer was firstly prepared, then chemically attached onto CS non-woven surface through the fast and efficient 'click'-type interfacial reaction between CS primary amines and azlactone moieties. The CS non-woven surface functionalized with cationic carboxybetaine esters is able to kill bacteria effectively. Upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resulting zwitterionic surface can further prevent the attachment of proteins, platelets, erythrocytes and bacteria. This CS non-woven that switches from bactericidal performance during storage to antifouling property before its service has great potential in wound dressing applications.
