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Related Concept Videos

Teeth01:15

Teeth

1.8K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Chiral synthesis and enzymatic resolution of (S)-(-)piperazine-2-carboxylic acid using enzyme alcalase.

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[The model of piggyback orthotopic liver transplantation in pigs].

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Related Experiment Video

Updated: Feb 8, 2026

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats
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Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats

Published on: August 25, 2020

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Stem Cells in Teeth and Craniofacial Bones.

H Zhao1, Y Chai2

  • 1Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.

Journal of Dental Research
|September 10, 2015
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for regenerating damaged tissues, particularly in dentistry and facial reconstruction. This review explores craniofacial stem cells for restoring teeth and bone defects.

Keywords:
Gli1 proteinhedgehogsmesenchymal stromal cellsneural crestskullstem cell niche

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Area of Science:

  • Biomedical Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Stem cells are crucial for tissue repair and regeneration.
  • Stem cell-based tissue engineering aims to restore damaged tissues or organs.
  • Restoring lost teeth and craniofacial bone defects is a key interest in dentistry and reconstructive surgery.

Purpose of the Study:

  • To review current knowledge on tooth- and craniofacial bone-related stem cells.
  • To discuss the in vivo identities of these stem cells.
  • To explore the regulating mechanisms of craniofacial stem cell regeneration.

Main Methods:

  • Literature review of existing research on stem cells in craniofacial regeneration.
  • Analysis of identified stem cell populations in the craniofacial region.
  • Discussion of stem cell identities and regulatory mechanisms.

Main Results:

  • Various stem cell populations with regeneration potential exist in the craniofacial region.
  • Understanding their in vivo identities is crucial for therapeutic applications.
  • Regulatory mechanisms governing these stem cells are key to successful regeneration.

Conclusions:

  • Stem cell-mediated therapy holds significant potential for dental and craniofacial bone defect restoration.
  • Further research into the identity and regulation of craniofacial stem cells is warranted.
  • This review provides a foundation for future studies in stem cell-based craniofacial tissue engineering.