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A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro
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Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Juliane Junesch1, Gustav Emilsson, Kunli Xiong
1Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden. adahlin@chalmers.se.
Nanoscale
|September 10, 2015
Abstract:
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

