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Three New Triterpenoids from European Mushroom Tricholoma terreum

Tao Feng1, Juan He2, Hong-Lian Ai3

  • 1College of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, China. fengtao@mail.kib.ac.cn.

Natural Products and Bioprospecting
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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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