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Intestinal Amyloidosis in Common Variable Immunodeficiency and Rheumatoid Arthritis
T Meira1, R Sousa1, A Cordeiro2
1Gastroenterology Department, Hospital Garcia de Orta E.P.E., Avenida Torrado da Silva, 2801-951 Almada, Portugal.
Case Reports in Gastrointestinal Medicine
|September 10, 2015
Summary
Reactive amyloidosis, a rare cause of chronic diarrhea, can develop secondary to common variable immunodeficiency and rheumatoid arthritis. This case highlights the importance of considering gastrointestinal amyloidosis in patients with chronic inflammatory conditions.
Area of Science:
- Immunology
- Gastroenterology
- Pathology
Background:
- Reactive amyloidosis is a rare condition often associated with chronic inflammatory diseases.
- Common variable immunodeficiency and rheumatoid arthritis are chronic inflammatory conditions.
- Gastrointestinal involvement in amyloidosis can present as chronic diarrhea.
Purpose of the Study:
- To report a case of reactive amyloidosis secondary to common variable immunodeficiency and rheumatoid arthritis.
- To emphasize the importance of considering gastrointestinal amyloidosis in the differential diagnosis of chronic diarrhea.
Main Methods:
- Case presentation of a 66-year-old woman.
- Diagnostic workup included colonoscopy with ileoscopy and biopsy.
- Histopathological examination of biopsies for amyloid deposition.
Main Results:
- Endoscopic examination revealed no significant findings.
- Biopsies confirmed amyloid deposition in the gastrointestinal tract.
- The patient had a history of common variable immunodeficiency and rheumatoid arthritis.
Conclusions:
- Reactive amyloidosis can be a cause of chronic diarrhea, particularly in patients with underlying chronic inflammatory diseases.
- Gastrointestinal amyloidosis should be suspected in patients with unexplained chronic diarrhea and inflammatory conditions.
- Early diagnosis and consideration of amyloidosis are crucial for appropriate management.
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