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Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully

Hikmet Gulsah Tanyildiz1, Sule Yesil1, Sule Toprak1

  • 1Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, Turkey.

Case Reports in Infectious Diseases
|September 10, 2015
PubMed

Insights

This study reports successful voriconazole treatment for Trichosporon asahii infections in two pediatric oncology patients with neutropenia. Early and appropriate antifungal therapy is crucial for survival in these high-risk invasive fungal infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatric Oncology

Background:

  • Trichosporon asahii is an opportunistic fungus causing infections in immunocompromised individuals.
  • Neutropenia, often due to malignancies, significantly increases the risk of invasive fungal infections.
  • Trichosporon asahii infections can lead to fatal sepsis and invasive disease.

Purpose of the Study:

  • To present two pediatric oncology cases of Trichosporon asahii infection successfully treated with voriconazole.
  • To highlight the challenges and potential outcomes of treating invasive fungal infections in neutropenic pediatric patients.

Main Methods:

  • Case report of two pediatric patients with hematologic malignancies and neutropenia.
  • Treatment with voriconazole for confirmed Trichosporon asahii infection.
  • Monitoring of patient response and outcomes.

Main Results:

  • Both pediatric patients with Trichosporon asahii infection achieved successful treatment outcomes with voriconazole.
  • Voriconazole demonstrated efficacy in these specific cases, despite literature suggesting limited effectiveness.
  • Early initiation of appropriate antifungal therapy was a key factor in patient survival.

Conclusions:

  • Voriconazole can be an effective treatment for Trichosporon asahii infections in select pediatric oncology patients.
  • Prompt and proper administration of antifungal agents is critical for managing potentially fatal invasive fungal infections.
  • Further research is needed to establish definitive treatment guidelines for Trichosporon asahii in neutropenic patients.

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