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Relationship between matrix metalloproteinase-9 and oxidative stress in drug-free male schizophrenia: a case control

Sivasankar Devanarayanan, Hanumanthappa Nandeesha, Shivanand Kattimani

    Clinical Chemistry and Laboratory Medicine
    |September 10, 2015
    PubMed
    Abstract

    Insights

    Schizophrenia involves increased matrix metalloproteinase-9 (MMP-9) and oxidative stress markers like malondialdehyde (MDA), with reduced total antioxidant status (TAS). These factors correlate with each other but not directly with disease severity.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Psychiatry

    Background:

    • Schizophrenia pathogenesis involves synaptic plasticity deregulation and oxidative stress.
    • Matrix metalloproteinase-9 (MMP-9) regulates synaptic plasticity.
    • Malondialdehyde (MDA) indicates lipid peroxidation and is elevated in schizophrenia.

    Purpose of the Study:

    • To assess serum levels of MMP-9, MDA, and total antioxidant status (TAS) in schizophrenia.
    • To investigate the association between MMP-9, MDA, TAS, and schizophrenia.

    Main Methods:

    • Study included 40 schizophrenia cases and 40 controls.
    • Serum MMP-9, MDA, and TAS were measured.
    • Disease severity assessed using the Positive and Negative Syndrome Scale (PANSS).

    Main Results:

    • Significantly higher MMP-9 and MDA levels in cases vs. controls.
    • Significantly lower TAS in cases vs. controls.
    • MMP-9 positively correlated with MDA and negatively with TAS; TAS correlated with symptom scores.

    Conclusions:

    • MMP-9 and oxidative stress are elevated and interconnected in schizophrenia.
    • While TAS correlated with disease severity, MMP-9 and MDA did not show association with symptom severity.

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