The effect of hepatitis B vaccine in dental students

The effect of Hevac B vaccine was studied in 57 seronegative dental students. Vaccines were given three monthly injections and booster at a year. Sera were collected at month 1, 2, 4, 12 and 13. Anti-HBs seroconversion rate were 5.26 per cent, 43.86 per cent and 82.45 per cent after the first, second and third injections. At a year, the seroconversion rate was 89.47 per cent and increased to 100.00 per cent at one month after the booster dose. Geometric mean titer after three injections was 324 IU/L. After booster vaccination, geometric mean titer was 5321 IU/L in 44 students, and the other 13 students had titer greater than 18,000 IU/L. Anti-HBc were detected in one male and one female students who had no clinical symptom of hepatitis. The HBsAg could not be detected and the transaminase enzyme were in normal limit in all collected specimens.