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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Related Experiment Video

Updated: Apr 4, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Does progesterone administration in preterm labor influence Treg cells?

Ana Luísa Areia, Sofia Vale-Pereira, Ana Vaz-Ambrósio

    Journal of Perinatal Medicine
    |September 10, 2015
    PubMed
    Summary

    Progesterone treatment significantly increased regulatory T-cells (Treg) in women experiencing preterm labor. This finding suggests a potential mechanism for progesterone

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    In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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    Area of Science:

    • Immunology
    • Reproductive Medicine
    • Obstetrics

    Background:

    • Preterm labor is a significant concern in obstetrics.
    • The role of progesterone in managing preterm labor is not fully understood.
    • Regulatory T-cells (Tregs) play a crucial role in immune modulation.

    Purpose of the Study:

    • To investigate whether progesterone's effects on preterm labor involve the modulation of regulatory T-cell (Treg) percentages.
    • To explore the potential immunomodulatory mechanisms of progesterone in the context of preterm labor.

    Main Methods:

    • A cohort pilot study was conducted in a tertiary obstetrical unit.
    • Peripheral blood samples were collected from women with preterm labor undergoing tocolytic treatment.
    • The number and percentage of Treg cells were analyzed using flow cytometry before and after progesterone administration.

    Main Results:

    • Progesterone treatment led to a significant increase in the Treg cell pool.
    • Both the percentage (48.9% vs. 53%; P=0.07) and absolute number (14.8 vs. 56.5 cells/μL; P=0.046) of Treg cells showed a notable rise post-treatment.
    • A statistically significant increase in the absolute number of Treg cells was observed.

    Conclusions:

    • Progesterone treatment demonstrably increases the Treg cell pool in women with preterm labor.
    • This suggests an immunomodulatory mechanism through which progesterone may exert its beneficial effects.
    • The findings support a more rational application of progesterone for managing preterm labor.