ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients

Sylvia Chen1, Lyne Villeneuve, Derek Jonker

  • 1aPharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHU de Québec) Research Center and Faculty of Pharmacy bCHU de Québec Research Center and Faculty of Medicine, Laval University cCanada Research Chair in Pharmacogenomics, CHU de Québec Research Center, Québec, Canada dDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada eDepartment of Molecular Biology and Translational Research, Division of Experimental and Clinical Pharmacology, National Cancer Institute and Cancer for Molecular Biomedicine, Aviano, Italy fEshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, North Carolina, USA.

Abstract

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