Related Experiment Video
Updated: Apr 4, 2026

Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
Published on: February 27, 2020
Semi-Supervised Affinity Propagation with Soft Instance-Level Constraints
Abstract:
Soft-constraint semi-supervised affinity propagation (SCSSAP) adds supervision to the affinity propagation (AP) clustering algorithm without strictly enforcing instance-level constraints. Constraint violations lead to an adjustment of the AP similarity matrix at every iteration of the proposed algorithm and to addition of a penalty to the objective function. This formulation is particularly advantageous in the presence of noisy labels or noisy constraints since the penalty parameter of SCSSAP can be tuned to express our confidence in instance-level constraints. When the constraints are noiseless, SCSSAP outperforms unsupervised AP and performs at least as well as the previously proposed semi-supervised AP and constrained expectation maximization. In the presence of label and constraint noise, SCSSAP results in a more accurate clustering than either of the aforementioned established algorithms. Finally, we present an extension of SCSSAP which incorporates metric learning in the optimization objective and can further improve the performance of clustering.
Related Concept Videos
Constraints and Statical Determinacy
Affinity and Avidity
Associative Learning
Classical conditioning, also known...
Per-Unit Sequence Models
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility
Residuals and Least-Squares Property
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...