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Updated: Apr 4, 2026
08:59
Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
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Skin involvement in Dupuytren's disease.
1Department of Plastic and Reconstructive Surgery, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
The Journal of Hand Surgery, European Volume
|September 11, 2015
Summary
The palmar skin plays a significant role in Dupuytren's disease development and recurrence. Dermal fibromatosis, found in 50-70% of patients, suggests the skin
Area of Science:
- Hand surgery
- Dermatology
- Orthopedics
Background:
- The role of palmar skin in Dupuytren's disease (DD) development, propagation, and recurrence is not fully understood.
- Clinical assessment of skin involvement in DD is challenging, and its correlation with histological findings is uncertain.
Purpose of the Study:
- To investigate the relationship between palmar skin histology and Dupuytren's disease.
- To determine the prevalence of dermal fibromatosis in patients undergoing surgery for DD.
Main Methods:
- Prospective biopsy of palmar skin in patients undergoing fasciectomy or dermofasciectomy for primary or recurrent DD.
- Histological examination for dermal fibromatosis.
Main Results:
- Dermal fibromatosis was found in 50% of patients undergoing fasciectomy and 70% undergoing dermofasciectomy.
- Dermal fibromatosis was associated with greater preoperative angular deformity, palmar nodules, and manual labor occupations.
- Dermal fibromatosis was present even without clinical signs of skin involvement.
Conclusions:
- Dermal fibromatosis is common in Dupuytren's disease, often occurring without visible skin changes.
- The palmar skin may play a more significant role in the development and progression of Dupuytren's disease than previously recognized.
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