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Updated: Apr 4, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
Published on: January 29, 2018
SUMO-regulated transcription: challenging the dogma
Pierre Chymkowitch1, Aurélie Nguéa P1, Jorrit M Enserink1
1Department of Molecular Biology, Institute of Microbiology, Oslo University Hospital, Oslo, Norway.
Abstract:
The small ubiquitin-like modifier SUMO regulates many aspects of cellular physiology to maintain cell homeostasis, both under normal conditions and during cell stress. Components of the transcriptional apparatus and chromatin are among the most prominent SUMO substrates. The prevailing view is that SUMO serves to repress transcription. However, as we will discuss in this review, this model needs to be refined, because recent studies have revealed that SUMO can also have profound positive effects on transcription.
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