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Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series
Kenya Nishioka1, Tetsuo Hayashi1, Michimasa Suzuki2
1Department of Neurology, Juntendo University School of Medicine, Tokyo Medical University, Tokyo, Japan.
International Journal of Rheumatic Diseases
|September 11, 2015
Summary
Fibromyalgia syndrome (FMS) rarely complicates neurocognitive disorders (NCDs). This study found central sensitization may cause widespread pain in elderly patients with NCD.
Area of Science:
- Neurology
- Pain Medicine
- Geriatrics
Background:
- Fibromyalgia syndrome (FMS) is a rare complication of neurocognitive disorders (NCDs).
- Understanding the clinical manifestations and pathomechanisms of FMS in NCD patients is crucial.
Observation:
- Seven patients with FMS secondary to NCD (frontotemporal NCD or Alzheimer's disease) were studied.
- Patients experienced refractory widespread pain despite analgesics, with no identifiable organic cause.
- Brain imaging revealed temporal lobe and hippocampal atrophy, and medial temporal lobe hypoperfusion.
Findings:
- Neurodegenerative disorders are rarely complicated by FMS.
- FMS in NCD patients is associated with severe, refractory widespread pain.
- Central sensitization is a potential risk factor for widespread pain in elderly NCD patients.
Implications:
- This research highlights a rare but significant complication of NCDs.
- Findings suggest a need for increased awareness of FMS in elderly NCD patients.
- Central sensitization mechanisms warrant further investigation in this population.
Keywords:
Alzheimer's diseasefibromyalgiafrontotemporal neurocognitive disorderssingle photon emission computed tomographyMore Related Videos
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