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Entheseal involvement in systemic disorders.

Gleb Slobodin1,2, Doron Rimar3,4, Nina Boulman3,4

  • 1Internal Medicine A, Bnai Zion Medical Center, 47 Golomb St, Haifa, Israel. gslobodin@yahoo.com.

Clinical Rheumatology
|September 11, 2015
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Summary
This summary is machine-generated.

Entheses, the sites where tendons or ligaments attach to bone, can be affected in many systemic disorders. Further research is needed to fully understand enthesopathies and their impact.

Keywords:
EnthesisEnthesitisEnthesopathy

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Pathology

Background:

  • Entheses are crucial anatomical structures connecting musculoskeletal tissues.
  • Understanding entheseal involvement in systemic diseases is vital for diagnosis and treatment.

Purpose of the Study:

  • To review current data on entheseal involvement in systemic disorders.
  • To consolidate knowledge on enthesis physiology and pathology in various conditions.

Main Methods:

  • Systematic review of PubMed literature using "enthesis" and "enthesitis" as keywords.
  • Inclusion of cadaver-based studies and imaging modalities like ultrasonography and magnetic resonance imaging.

Main Results:

  • Detailed characterization of enthesis components and imaging techniques.
  • Elaboration of entheseal disease roles in spondyloarthropathies, juvenile idiopathic arthritis, osteoarthritis, familial Mediterranean fever, and hyperuricemia.
  • Demonstrated diverse ways entheses are affected across various systemic disorders with different pathogenetic mechanisms.

Conclusions:

  • Entheses are implicated in a wide spectrum of systemic disorders.
  • Enhanced understanding of entheseal involvement is a critical first step in addressing related enigmas.
  • Further investigation into risk factors, mechanisms, and natural history of enthesopathies is warranted.