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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
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Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery
Tahnee J Dening1, Shasha Rao1, Nicky Thomas1
1School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5001, Australia.
The AAPS Journal
|September 11, 2015
Summary
Solid-state lipid-based drug delivery systems (LBDDS) offer improved oral delivery for poorly soluble drugs. Choosing the right solid carrier is crucial for optimizing drug release and biopharmaceutical performance.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Lipid-based drug delivery systems (LBDDS) are vital for oral delivery of poorly water-soluble drugs.
- Conventional LBDDS face limitations hindering widespread use and commercialization.
- A gap exists between LBDDS potential and their application for challenging drugs.
Purpose of the Study:
- To review the impact of solid carrier selection on LBDDS performance.
- To highlight the importance of solid carriers in hybrid solid-state LBDDS.
- To explore novel materials for solid carrier applications in LBDDS.
Main Methods:
- Review of existing literature on solid-state LBDDS.
- Analysis of how solid carriers influence drug release kinetics.
- Evaluation of solid carrier effects on lipase action and lipid digestion.
Main Results:
- Solid carriers stabilize LBDDS and overcome limitations of liquid formulations.
- Carrier choice significantly modulates drug release profiles.
- Appropriate carriers enhance biopharmaceutical performance beyond liquid LBDDS.
Conclusions:
- Solid carrier selection is critical for successful solid-state LBDDS design.
- This review guides future research and development in solid-state LBDDS.
- Optimized solid-state LBDDS show promise for pharmaceutical market translation.
Keywords:
lipid-based drug delivery systemsoral bioavailabilitypoorly water-soluble drugssolid carrierssolid dosage formsMore Related Videos
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