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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

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Chronic obstructive pulmonary diseases in children.

Jose Dirceu Ribeiro¹, Gilberto Bueno Fischer²

¹Department of Pediatrics, Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.

Jornal De Pediatria

|September 11, 2015

Summary

Chronic obstructive pulmonary diseases in children and adolescents (COPDC) can be managed effectively with guideline-based treatments and patient adherence. Early diagnosis and individualized care are key to controlling symptoms and improving quality of life.

Keywords:

Child Chronic cough Chronic obstructive pulmonary disease Criança Doença pulmonar obstrutiva crônica Tosse crônica

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Area of Science:

Pediatric Pulmonology
Respiratory Medicine
Genetics and Environmental Health

Background:

Chronic obstructive pulmonary diseases in children and adolescents (COPDC) present with diverse genetic and environmental origins.
Manifestations include varied genotypes, phenotypes, and endotypes, with chronic cough as a primary symptom and potential bronchiectasis.

Purpose of the Study:

To review and describe the key aspects of diagnosing and managing COPDC in pediatric and adolescent populations.
To consider the interplay of physiopathology, genetics, and environmental factors in COPDC.

Main Methods:

A comprehensive literature review of relevant studies was conducted using the PubMed database.

Main Results:

COPDC, while incurable, is manageable through individualized treatment plans.
Effective management relies on adherence to guidelines and treatment regimens, including corticosteroids, bronchodilators, and inhaled antibiotics.
Pulmonary exacerbations (PE) are a critical factor in management and outcome assessment.

Conclusions:

Accurate diagnosis, understanding risk factors, and managing comorbidities are crucial for effective COPDC management.
Treatment strategies must be guideline-based and individualized, with patient adherence being paramount.
Long-term outcomes are improved through interdisciplinary team monitoring in specialized centers, focusing on reduced PEs, enhanced quality of life, and preserved lung function.