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Viral Hemorrhagic Fever Diagnostics.

Lori D Racsa1, Colleen S Kraft1, Gene G Olinger2

  • 1Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 11, 2015
PubMed
Summary

Viral hemorrhagic fever (VHF) diagnosis is critical for outbreak control. This review covers traditional and current diagnostic methods for VHF, essential for global laboratories.

Keywords:
Eboladiagnosticsviral hemorrhagic fever

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Area of Science:

  • Virology and Infectious Diseases
  • Diagnostic Medicine

Background:

  • Viral hemorrhagic fever (VHF) is caused by four virus families, including Filoviridae.
  • Ebola virus, a Filoviridae, is responsible for the current West Africa outbreak.
  • Traditional VHF diagnostics are centralized in developed countries, limiting access in endemic regions.

Purpose of the Study:

  • To review traditional and current diagnostic modalities for viral hemorrhagic fever (VHF).
  • To highlight the importance of rapid VHF diagnosis for outbreak containment.
  • To underscore the necessity of understanding VHF diagnostics globally due to increased travel.

Main Methods:

  • Review of existing literature on traditional diagnostic techniques for VHF.
  • Analysis of current diagnostic approaches and emerging technologies for VHF.
  • Discussion of diagnostic challenges and requirements in resource-limited settings.

Main Results:

  • Traditional VHF diagnostics require significant resources and specialized personnel.
  • Current diagnostic methods are being adapted for faster and more accessible testing.
  • Decentralized diagnostic capabilities are crucial for effective VHF outbreak response.

Conclusions:

  • Accessible and rapid VHF diagnostics are essential for global health security.
  • Understanding diverse diagnostic modalities is imperative for laboratories worldwide.
  • Advancements in diagnostics are needed to support timely identification and management of VHF cases.