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NS1: A corner piece in the dengue pathogenesis puzzle?

Stephen J Thomas1

  • 1Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. stephen.j.thomas3.mil@mail.mil.

Science Translational Medicine
|September 11, 2015
PubMed
Summary

Soluble dengue virus non-structural protein 1 (NS1) triggers inflammatory responses through Toll-like receptor 4. This interaction damages endothelial cells, leading to dangerous vascular leakage during dengue infection.

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