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Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome
Yu-Zhong Wang1,2, Hui Lv3, Qi-Guang Shi1
1Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Abstract:
Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits. Corticosteroids may reduce the scavengers that play a crucial role for nerve regeneration, thus delay the recovery of this disease.
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