Related Experiment Video
Updated: Apr 4, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
Effects of Priming and Pacing Strategy on Oxygen-Uptake Kinetics and Cycling Performance
Stephen J Bailey1, Anni Vanhatalo, Matthew I Black
1College of Life and Environmental Sciences, University of Exeter, Devon, UK.
Purpose:
To assess whether combining prior "priming" exercise with an all-out pacing strategy is more effective at improving oxygen-uptake (VO2) kinetics and cycling performance than either intervention administered independently.
Methods:
Nine men completed target-work cycling performance trials using a self-paced or all-out pacing strategy with or without prior severe-intensity (70%Δ) priming exercise. Breath-by-breath pulmonary VO2 and cycling power output were measured during all trials.
Results:
Compared with the self-paced unprimed control trial (22 ± 5 s), the VO2 mean response time (MRT) was shorter (VO2 kinetics were faster) with all-out pacing (17 ± 4 s) and priming (17 ± 3 s), with the lowest VO2 MRT observed when all-out pacing and priming were combined (15 ± 4 s) (P < .05). However, total O2 consumed and end-exercise VO2 were only higher than the control condition in the primed trials (P < .05). Similarly, cycling performance was improved compared with control (98 ± 11 s) in the self-paced primed (93 ± 8 s) and all-out primed (92 ± 8 s) trials (P < .05) but not the all-out unprimed trial (97 ± 5 s; P > .05).
Conclusions:
These findings suggest that combining an all-out start with severe-intensity priming exercise additively improves VO2 MRT but not total O2 consumption and cycling performance since these were improved by a similar magnitude in both primed trials relative to the self-paced unprimed control condition. Therefore, these results support the use of priming exercise as a precompetition intervention to improve oxidative metabolism and performance during short-duration high-intensity cycling exercise, independent of the pacing strategy adopted.
More Related Videos
Related Concept Videos
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Oxygen Transport in the Blood
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...

