SOCE and cancer: Recent progress and new perspectives.

Area of Science:

• Cellular Biology
• Molecular Biology
• Cancer Research

Background:

• Calcium ions (Ca2+) are vital second messengers regulating diverse cellular functions.
• Store-operated calcium entry (SOCE) is a primary calcium influx pathway in non-excitable cells, involving STIM proteins sensing ER calcium depletion to gate ORAI channels.
• SOCE is implicated in critical cancer processes like proliferation, metastasis, and angiogenesis, and also influences antitumor immunity.

Purpose of the Study:

• To review recent advancements in understanding SOCE function in various cancer-related cells.
• To explore the role of SOCE in tumor cells, vascular endothelial cells, and immune cells.
• To discuss the therapeutic potential of SOCE inhibitors for cancer treatment.

Main Methods:

• Literature review of recent scientific publications.
• Synthesis of findings on SOCE mechanisms and functions.
• Analysis of therapeutic implications of targeting SOCE in cancer.

Main Results:

• SOCE is essential for cancer cell proliferation, migration, and neovascularization.
• SOCE modulates the activity of immune cells involved in antitumor responses.
• Dysregulation of SOCE is a common feature in various cancer types.

Conclusions:

• SOCE is a key regulator of cancer cell behavior and the tumor microenvironment.
• Inhibitors of SOCE represent a potential therapeutic avenue for cancer management.
• Further research into SOCE pathways could unveil novel cancer treatment strategies.