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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

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52 additional reference population samples for the 55 AISNP panel.

Andrew J Pakstis¹, Eva Haigh¹, Lotfi Cherni²

¹Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Forensic Science International. Genetics

|September 11, 2015

Summary

This summary is machine-generated.

Researchers expanded the available reference population data for ancestry inference using SNP (single nucleotide polymorphism) analysis. This update increases the total number of population samples with publicly available allele frequencies to 125, aiding genetic studies.

Keywords:

ALFRED Ancestry FROG-kb Reference database SNP

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Area of Science:

Population Genetics
Human Ancestry
Bioinformatics

Background:

Ancestry inference relies on Single Nucleotide Polymorphism (SNP) frequency variations globally and available reference data.
The Kidd Lab's 55 AISNP panel is integrated into commercial massively parallel sequencing kits (Life Technologies, Illumina).
Expanding reference population data is crucial for researchers utilizing these commercial kits.

Purpose of the Study:

To augment the publicly available reference population data for SNP-based ancestry inference.
To support researchers using commercial sequencing kits that incorporate the Kidd Lab's SNP panel.

Main Methods:

Added allele frequencies for 52 new population samples.
Integrated new data with 73 existing population samples.
Made allele frequencies publicly accessible via ALFRED and FROG-kb databases.

Main Results:

Increased the total number of population samples with publicly available allele frequencies to 125.
Enhanced the utility of existing SNP panels for global population studies.

Conclusions:

The expanded dataset provides a more comprehensive resource for human ancestry inference.
Increased reference data improves the accuracy and applicability of SNP-based genetic analyses.