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Updated: Apr 4, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
[Endogenous venous thrombolysis]
O Ya Porembskaya1, S M Khmelniker2, E V Shaidakov1
1Centre for Diagnosis and Treatment of Venous Diseases, Clinic of Scientific Research Institute of Experimental Medicine, North-West Branch of the RAMS, St. Petersburg, Russia.
Abstract:
Widely incorporated into vascular surgery pharmacological thrombolysis in treatment for deep vain thrombosis is fraught with a series of unsolved problems requiring further consideration. In spite of aggressive nature of treatment in a series of cases pharmacological thrombolysis sometimes turns out ineffective. Along with it, the results of experimental studies suggest a possibility of accelerating resorption of thrombotic masses and inhibiting remodelling of the venous wall by means of influencing effector cells of endogenous thrombolysis. A detailed study of the mechanisms of thrombolysis would make it possible to formulate strict criteria for carrying out pharmacological thrombolysis and to increase its efficacy.
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