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Sinonasal Leiomyoma With Estrogen Receptor Expression
Jong Seung Kim1, Jin Yong Shin, Sam Hyun Kwon
1*Department of Otolaryngology-Head and Neck Surgery †Department of Plastic and Reconstructive Surgery, Chonbuk National University ‡Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
The Journal of Craniofacial Surgery
|September 11, 2015
Summary
This study reports an extremely rare sinonasal leiomyoma in a woman, originating from the lacrimal bone. The tumor expressed estrogen receptors, a unique finding not previously documented in medical literature.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Leiomyomas are typically found in smooth muscle-rich areas, making sinonasal leiomyomas exceptionally rare due to the limited smooth muscle in the nasal cavity.
- The etiology and origin of sinonasal leiomyomas remain unclear, with minimal documented cases in scientific literature.
Observation:
- A 58-year-old female presented with nasal obstruction and epiphora.
- A large mass was identified in the right nasal cavity, arising from the lacrimal bone region.
Findings:
- Endoscopic sinus surgery was performed, and the specimen confirmed a sinonasal leiomyoma.
- Immunohistochemistry revealed the tumor expressed estrogen receptors (ER) but not progesterone receptors (PR).
Implications:
- This case represents the first documented instance of a sinonasal leiomyoma expressing estrogen receptors.
- The findings may contribute to understanding the potential hormonal influences on rare sinonasal tumors.
