Related Experiment Video
Updated: Apr 4, 2026

07:33
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
Published on: October 15, 2018
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Controlling release, unfolding and dissociation of membrane protein complexes in the gas phase through collisional
Michael Landreh1, Idlir Liko, Povilas Uzdavinys
1Department of Chemistry, Theoretical and Physical Chemistry Laboratory, University of Oxford, Oxford OX1 3TA, UK. Carol.Robinson@chem.ox.ac.uk.
Abstract:
Mass spectrometry of intact membrane protein complexes requires removal of the detergent micelle by collisional activation. We demonstrate that the necessary energy can be obtained by adjusting the degree of collisional cooling in the ion source. This enables us to extend the energy regime for dissociation of membrane protein complexes.

