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Maternal-Fetal Hepatitis E Transmission: Is It Underestimated?
Maysaa El Sayed Zaki1, Mohammed Magdy Abd El Razek2, Hassan Magdy Abd El Razek1
1Clinical Pathology, Mansoura Faculty of Medicine, Egypt.
Journal of Clinical and Translational Hepatology
|September 11, 2015
Summary
Hepatitis E virus (HEV) during pregnancy poses risks to mothers and newborns. This review summarizes HEV
Area of Science:
- Virology
- Maternal-Fetal Medicine
- Public Health
Background:
- Hepatitis E virus (HEV) is an enterically transmitted pathogen.
- Transmission routes include person-to-person, blood transfusion, and transplacental routes.
- HEV infection during pregnancy is linked to adverse maternal and fetal outcomes.
Purpose of the Study:
- To review the impact of Hepatitis E virus infection on maternal and fetal health.
- To explore HEV's effects across different clinical scenarios in pregnancy.
- To consolidate current knowledge on HEV's obstetric and neonatal implications.
Main Methods:
- Literature review of studies on HEV and pregnancy.
- Synthesis of data on maternal prognosis and HEV.
- Analysis of outcomes related to transplacental HEV transmission.
- Examination of neonatal complications associated with maternal HEV.
Main Results:
- HEV infection in pregnant women is associated with poor maternal prognosis.
- Severe cases can lead to acute fulminant hepatitis and maternal mortality.
- Transplacental HEV transmission frequently results in fetal loss and preterm labor.
- Neonates exposed to HEV in utero may exhibit hepatic dysfunction.
Conclusions:
- HEV poses significant risks to both maternal and fetal well-being.
- Transplacental transmission is a critical factor in adverse pregnancy outcomes.
- Understanding HEV's effects is crucial for managing pregnant populations.
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