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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase

Lihan Zhang1, Takahiro Mori1, Qingfei Zheng2

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

Angewandte Chemie (International Ed. in English)
|September 11, 2015
PubMed

Keywords:
biosynthesiscrotonyl-CoA carboxylase/reductasepolyketidesprotein engineering

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