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Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
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[Genetic aspects of migraine]
S V Kopishinskaya1, A V Gustov1
1Nizhny Novgorod State Medical Academy, Nizhny Novgorod.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|September 11, 2015
Summary
Migraine, a neurological disorder, involves genetic factors and the serotonin system. Impaired serotonin metabolism in celiac disease can trigger migraine-like headaches.
Area of Science:
- Neurology
- Genetics
- Gastroenterology
Context:
- Migraine is a prevalent neurological disorder.
- Genetic mutations are implicated in migraine development, particularly familial hemiplegic migraine.
- The serotonin system is crucial in migraine pathogenesis.
Purpose:
- To explore the link between celiac disease, serotonin metabolism, and migraine.
- To review arteriopathies associated with migraine.
Summary:
- Migraine involves severe headaches, nausea, vomiting, and sensory hypersensitivity.
- Neurological symptoms (aura) occur in 25% of patients.
- Celiac disease, a chronic enteropathy, is associated with migraine-like headaches due to impaired serotonin metabolism.
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), retinal vasculopathy with cerebral leukodystrophy (RVCL), hereditary systemic angiopathy (HSA), and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) are arteriopathies linked to migraine.
Impact:
- Highlights the connection between gastrointestinal health and neurological conditions.
- Emphasizes the role of serotonin in migraine pathophysiology.
- Provides an overview of genetic and vascular factors contributing to migraine.
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