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Related Concept Videos

Aging01:26

Aging

1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Cognitive Development During Adulthood01:30

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Related Experiment Video

Updated: Apr 4, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Global Network Alignment in the Context of Aging.

Fazle Elahi Faisal, Han Zhao, Tijana Milenkovic

    IEEE/ACM Transactions on Computational Biology and Bioinformatics
    |September 11, 2015
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    Summary

    Network alignment (NA) effectively transfers biological knowledge between species. A novel NA method combining specific cost functions and alignment strategies outperforms existing approaches, revealing new insights into human aging.

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    Area of Science:

    • Computational Biology
    • Bioinformatics
    • Systems Biology

    Background:

    • Network alignment (NA) facilitates cross-species biological knowledge transfer by identifying conserved network regions.
    • Existing NA methods face challenges in selecting optimal cost functions and alignment strategies for accurate similarity assessment.
    • Current aging research heavily relies on sequence alignment, with limited exploration of network-based approaches.

    Purpose of the Study:

    • To evaluate combinations of existing cost functions and alignment strategies in network alignment.
    • To develop a novel, superior network alignment method by optimizing these combinations.
    • To apply the improved NA method for discovering novel human aging-related genes and knowledge.

    Main Methods:

    • Systematic evaluation of various cost functions and alignment strategies from state-of-the-art network alignment methods.
    • Development of a hybrid network alignment approach by combining the most effective cost function and alignment strategy.
    • Application of the novel NA method to transfer aging-related biological knowledge from model organisms to humans.

    Main Results:

    • A novel network alignment method, combining a specific cost function with a distinct alignment strategy, demonstrated superior performance over existing methods.
    • The study successfully generated novel human aging-related knowledge by transferring data from well-annotated species.
    • Predicted aging-related genes showed significant topological and functional similarity to known aging genes.

    Conclusions:

    • The proposed hybrid network alignment method offers a more effective approach for biological network comparison.
    • Network alignment is a powerful tool for uncovering new biological insights, particularly in complex areas like human aging.
    • This study represents the first application of network alignment to advance the understanding of human aging.