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Prognostic comparison of Behçet's disease with or without HLA-Bw 51 antigen
Insights
This study found that the presence of the HLA-Bw 51 antigen is significantly associated with an increased prevalence of skin lesions in Behçet
Area of Science:
- Immunogenetics
- Rheumatology
- Ophthalmology
Background:
- Behçet's disease is a multisystem inflammatory disorder.
- The role of human leukocyte antigen (HLA) Bw 51 in disease prognosis is under investigation.
Purpose of the Study:
- To investigate the prognosis of Behçet's disease in relation to the HLA-Bw 51 antigen.
- To compare clinical manifestations between HLA-Bw 51 positive and negative patients.
Main Methods:
- Retrospective analysis of 24 Behçet's disease cases.
- Classification based on clinical and ocular types.
- Comparison of symptom prevalence between HLA-Bw 51 positive and negative groups.
Main Results:
- A statistically significant higher incidence of skin lesions was observed in HLA-Bw 51 positive patients (70%) compared to negative patients (30%) (p < 0.01).
- No significant differences were found in other general symptoms or visual acuity between the groups (p > 0.1).
- Ocular inflammation distribution showed minor variations between the groups.
Conclusions:
- The HLA-Bw 51 antigen is strongly associated with the development of skin lesions in Behçet's disease.
- HLA-Bw 51 status may not significantly impact other general symptoms or visual acuity in this cohort.
Abstract:
To know the prognosis of Behçet's disease with HLA-Bw 51 antigen, comparison studies of 24 cases of Behçet's disease were investigated. The sex distribution was 14 males (58%) and 10 females (42%). The patients were grouped into three clinical types: the complete type with 11 cases (45%), the incomplete type with eight cases (33%) and the suspect type with five cases (22%), according to the criteria established by the Behçet's Disease Research Committee in Japan (1982). They were also divided into three ocular types according to the location of the inflammation: the anterior segment type, the fundus type and the mixed type. They were divided into 10%, 10% and 60% in HLA-Bw 51 negative group and 14%, 22% and 64% in HLA-Bw 51 positive group, respectively. Skin lesions observed in 30% of the HLA-Bw 51 negative group and 70% of the HLA-Bw 51 positive group, which was statistically significant (p less than 0.01). The other general symptoms and the visual acuity between the two groups were not statistically significant (p greater than 0.1).