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Updated: Apr 4, 2026

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
Published on: April 9, 2017
G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
Mi-Jin Kim1, Tae-Hee Kim2, Hae-Hyeog Lee2
1Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. ; Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University, Asan, Korea.
Abstract:
Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.
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